Human CBR1 protein (Recombinant) (N-His) (STJP006583)

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STJP006583
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CBR1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CBR1
Gene ID: 873
Uniprot ID: CBR1_HUMAN
Immunogen Region: Met1-Trp277
Immunogen: Homo sapiens (Human)
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
Protein Name Carbonyl Reductase Nadph 1
15-Hydroxyprostaglandin Dehydrogenase Nadp(+
20-Beta-Hydroxysteroid Dehydrogenase
Alcohol Dehydrogenase Nad(P+ Cbr1
Nadph-Dependent Carbonyl Reductase 1
Prostaglandin 9-Ketoreductase
Pg-9-Kr
Prostaglandin-E(2 9-Reductase
Short Chain Dehydrogenase/Reductase Family 21c Member 1
Database Links Reactome: R-HSA-2162123
Cellular Localisation Cytoplasm
Alternative Protein Names Carbonyl Reductase Nadph 1 protein
15-Hydroxyprostaglandin Dehydrogenase Nadp(+ protein
20-Beta-Hydroxysteroid Dehydrogenase protein
Alcohol Dehydrogenase Nad(P+ Cbr1 protein
Nadph-Dependent Carbonyl Reductase 1 protein
Prostaglandin 9-Ketoreductase protein
Pg-9-Kr protein
Prostaglandin-E(2 9-Reductase protein
Short Chain Dehydrogenase/Reductase Family 21c Member 1 protein
CBR1 protein
CBR protein
CRN protein
SDR21C1 protein

Information sourced from Uniprot.org

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