Human CBLL1 protein (Recombinant) (N-His-SUMO) (STJP008796)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CBLL1-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CBLL1 |
| Gene ID | 79872 |
| Uniprot ID | HAKAI_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys117-His190 |
Additional Info
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. |
| Protein Name | E3 Ubiquitin-Protein Ligase HakaiCasitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1C-Cbl-Like Protein 1Ring Finger Protein 188Ring-Type E3 Ubiquitin Transferase Hakai |
| Database Links | Reactome: R-HSA-8876493 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Hakai proteinCasitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 proteinC-Cbl-Like Protein 1 proteinRing Finger Protein 188 proteinRing-Type E3 Ubiquitin Transferase Hakai proteinCBLL1 proteinHAKAI proteinRNF188 protein |
Information sourced from Uniprot.org