Human CBLL1 protein (Recombinant) (N-His-SUMO) (STJP008796)

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STJP008796
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CBLL1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CBLL1
Gene ID: 79872
Uniprot ID: HAKAI_HUMAN
Immunogen Region: Lys117-His190
Immunogen: Homo sapiens (Human)
Function E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
Protein Name E3 Ubiquitin-Protein Ligase Hakai
Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1
C-Cbl-Like Protein 1
Ring Finger Protein 188
Ring-Type E3 Ubiquitin Transferase Hakai
Database Links Reactome: R-HSA-8876493
Cellular Localisation Nucleus Speckle
Nucleus
Nucleoplasm
Cytoplasm
Mainly Nuclear With Some Fraction Located In The Cytoplasm
Zc3h13 Is Required To Anchor Component Of The Macom Subcomplex
Such As Virma
In The Nucleus
Alternative Protein Names E3 Ubiquitin-Protein Ligase Hakai protein
Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1 protein
C-Cbl-Like Protein 1 protein
Ring Finger Protein 188 protein
Ring-Type E3 Ubiquitin Transferase Hakai protein
CBLL1 protein
HAKAI protein
RNF188 protein

Information sourced from Uniprot.org

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