• Human Cathepsin S protein (Active Recombinant) (C-His) (STJP000955)

Human Cathepsin S protein (Active Recombinant) (C-His) (STJP000955)

SKU:
STJP000955

Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of 50mM MES, 100mM NaCl, pH 6.5.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The specific activity is >1390 pmol/min/Mu g.
Gene Symbol: CTSS
Gene ID: 1520
Uniprot ID: CATS_HUMAN
Immunogen Region: Gln17-Ile331
Immunogen: Recombinant Human Cathepsin S Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln17-Ile331) of human Cathepsin S/CTSS (Accession #NP_004070.3) fused with an 8×His tag at the C-terminus.
Immunogen Sequence: QLHKDPTLDHHWHLWKKTYG KQYKEKNEEAVRRLIWEKNL KFVMLHNLEHSMGMHSYDLG MNHLGDMTSEEVMSLMSSLR VPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSC GACWAFSAVGALEAQLKLKT GKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNK GIDSDASYPYKAMDQKCQYD SKYRAATCSKYTELPYGRED VLKEAVANKGPVSVGVDAR
Function Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Protein Name Cathepsin S
Database Links Reactome: R-HSA-1236977
Reactome: R-HSA-1474228
Reactome: R-HSA-1679131
Reactome: R-HSA-2022090
Reactome: R-HSA-2132295
Reactome: R-HSA-6798695
Cellular Localisation Lysosome
Secreted
Cytoplasmic Vesicle
Phagosome
Alternative Protein Names Cathepsin S protein
CTSS protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance