• Human Cathepsin B protein (Recombinant) (C-His) (STJP002444)

Human Cathepsin B protein (Recombinant) (C-His) (STJP002444)

SKU:
STJP002444

£89.50 - £357.50
Current Stock:
Host: HEK293 Cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Cathepsin B-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTSB
Gene ID: 1508
Uniprot ID: CATB_HUMAN
Immunogen Region: Arg18-Ile339
Immunogen: Recombinant Human Cathepsin B Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Arg18-Ile339) of human Cathepsin B (Accession #NP_001899.1) fused with a 6×His tag at the C-terminus.
Function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis.
Protein Name Cathepsin B
App Secretase
Apps
Cathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1679131
Reactome: R-HSA-2022090
Reactome: R-HSA-2132295
Reactome: R-HSA-6798695
Cellular Localisation Lysosome
Melanosome
Secreted
Extracellular Space
Apical Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Localizes To The Lumen Of Thyroid Follicles And To The Apical Membrane Of Thyroid Epithelial Cells
Alternative Protein Names Cathepsin B protein
App Secretase protein
Apps protein
Cathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain protein
CTSB protein
CPSB protein

Information sourced from Uniprot.org

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