• Human Cathepsin B protein (Recombinant) (C-His) (STJP002444)

Human Cathepsin B protein (Recombinant) (C-His) (STJP002444)

SKU:
STJP002444

£106.50 - £359.50
Current Stock:
Host: HEK293 Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Immunoreactivity: Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC (R&D Systems, Catalog # ES008). The specific activity is >3468 pmoles/min/Mu g.
Gene Symbol: CTSB
Gene ID: 1508
Uniprot ID: CATB_HUMAN
Immunogen Region: Arg18-Ile339
Immunogen: Recombinant Human Cathepsin B Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Arg18-Ile339) of human Cathepsin B (Accession #NP_001899.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: RSRPSFHPLSDELVNYVNKR NTTWQAGHNFYNVDMSYLKR LCGTFLGGPKPPQRVMFTED LKLPASFDAREQWPQCPTIK EIRDQGSCGSCWAFGAVEAI SDRICIHTNAHVSVEVSAED LLTCCGSMCGDGCNGGYPAE AWNFWTRKGLVSGGLYESHV GCRPYSIPPCEHHVNGSRPP CTGEGDTPKCSKICEPGYSP TYKQDKHYGYNSYSVSNSEK DIMAEIYKNGPVEGAFSVY
Function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis.
Protein Name Cathepsin B
App Secretase
Apps
Cathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1679131
Reactome: R-HSA-2022090
Reactome: R-HSA-2132295
Reactome: R-HSA-6798695
Cellular Localisation Lysosome
Melanosome
Secreted
Extracellular Space
Apical Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Localizes To The Lumen Of Thyroid Follicles And To The Apical Membrane Of Thyroid Epithelial Cells
Alternative Protein Names Cathepsin B protein
App Secretase protein
Apps protein
Cathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain protein
CTSB protein
CPSB protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance