Human CASP2 protein (Recombinant) (N-His) (STJP004717)

SKU:
STJP004717
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CASP2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CASP2
Gene ID: 835
Uniprot ID: CASP2_HUMAN
Immunogen Region: Gly334-Thr452
Immunogen: Homo sapiens (Human)
Post Translational Modifications The mature protease can process its own propeptide, but not that of other caspases.
Function Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Isoform 1: Acts as a positive regulator of apoptosis. Isoform 2: Acts as a negative regulator of apoptosis. Isoform 3: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death.
Protein Name Caspase-2
Casp-2
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2
Nedd-2
Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12
Database Links Reactome: R-HSA-168638
Reactome: R-HSA-205025
Reactome: R-HSA-6803207
Alternative Protein Names Caspase-2 protein
Casp-2 protein
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 protein
Nedd-2 protein
Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 protein
CASP2 protein
ICH1 protein
NEDD2 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP007878 Human GPAT3 protein (Recombinant) (N-His) (STJP007878) E. coli
STJP007867 Human NAP1L4 protein (Recombinant) (N-His) (STJP007867) E. coli
STJP007854 Human EGLN1 protein (Recombinant) (N-His) (STJP007854) E. coli

Related Products

!