Human Calsequestrin 2/CASQ2 protein (Recombinant) (His-Tag) (STJP016643)

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STJP016643
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Calsequestrin 2/CASQ2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASQ2
Gene ID: 845
Uniprot ID: CASQ2_HUMAN
Immunogen Region: 20-399aa
Accession Number: NP_001223
Immunogen: Human
Immunogen Sequence: GSMEEG LNFPTYDGKD RVVSLSEKNF KQVLKKYDLL CLYYHEPVSS DKVTQKQFQL KEIVLELVAQ VLEHKAIGFV MVDAKKEAKL AKKLGFDEEG SLYILKGDRT IEFDGEFAAD VLVEFLLDLI EDPVEIISSK LEVQAFERIE DYIKLIGFFK SEDSEYYKAF EEAAEHFQPY IKFFATFDKG VAKKLS
Post Translational Modifications Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity. N-glycosylated.
Function Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2.this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Protein Name Calsequestrin-2
Calsequestrin - Cardiac Muscle Isoform
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-5578775
Cellular Localisation Sarcoplasmic Reticulum Lumen
This Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Cardiac And Slow Skeletal Muscle Cells
Alternative Protein Names Calsequestrin-2 protein
Calsequestrin - Cardiac Muscle Isoform protein
CASQ2 protein

Information sourced from Uniprot.org

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