Human CALHM6 protein (Recombinant) (N-His) (STJP007653)

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STJP007653
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CALHM6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CALHM6
Gene ID: 441168
Uniprot ID: CAHM6_HUMAN
Immunogen Region: Arg197-Ile309
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated.
Function Pore-forming subunit of an ATP-permeable channel. In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses. May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels.
Protein Name Calcium Homeostasis Modulator Protein 6
Protein Fam26f
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Recruited At Immune Synapses In Response To Pathogen-Derived And Proinflammatory Stimuli
Alternative Protein Names Calcium Homeostasis Modulator Protein 6 protein
Protein Fam26f protein
CALHM6 protein
C6orf187 protein
FAM26F protein

Information sourced from Uniprot.org

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