Human CALCRL protein (Recombinant) (N-His) (STJP005492)

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STJP005492
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CALCRL-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CALCRL
Gene ID: 10203
Uniprot ID: CALRL_HUMAN
Immunogen Region: Glu23-Glu133
Immunogen: Homo sapiens (Human)
Function G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
Protein Name Calcitonin Gene-Related Peptide Type 1 Receptor
Cgrp Type 1 Receptor
Calcitonin Receptor-Like Receptor
Crlr
Database Links Reactome: R-HSA-418555
Reactome: R-HSA-419812
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Calcitonin Gene-Related Peptide Type 1 Receptor protein
Cgrp Type 1 Receptor protein
Calcitonin Receptor-Like Receptor protein
Crlr protein
CALCRL protein
CGRPR protein

Information sourced from Uniprot.org

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