Human CACNA2D2 protein (Recombinant) (N-His) (STJP010996)

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STJP010996
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CACNA2D2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CACNA2D2
Gene ID: 9254
Uniprot ID: CA2D2_HUMAN
Immunogen Region: Asp291-Leu469
Immunogen: Homo sapiens (Human)
Post Translational Modifications May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Protein Name Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2
Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2
Database Links Reactome: R-HSA-112308
Reactome: R-HSA-400042
Reactome: R-HSA-422356
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Reactome: R-HSA-9662360
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Colocalizes With Cacna1a In Lipid Raft Fractions
Alternative Protein Names Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 protein
Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 protein
CACNA2D2 protein
KIAA0558 protein

Information sourced from Uniprot.org

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