Human CACNA1S protein (Recombinant) (N-His) (STJP005356)

SKU:
STJP005356
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CACNA1S-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CACNA1S
Gene ID: 779
Uniprot ID: CAC1S_HUMAN
Immunogen Region: Ala1657-Leu1873
Immunogen: Homo sapiens (Human)
Post Translational Modifications The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690. Phosphorylated. Phosphorylation by PKA activates the calcium channel. Both the minor and major forms are phosphorylated in vitro by PKA. Phosphorylation at Ser-1575 is involved in beta-adrenergic-mediated regulation of the channel.
Function Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle
Voltage-Gated Calcium Channel Subunit Alpha Cav1.1
Database Links Reactome: R-HSA-419037
Cellular Localisation Cell Membrane
Sarcolemma
T-Tubule
Multi-Pass Membrane Protein
Alternative Protein Names Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s protein
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle protein
Voltage-Gated Calcium Channel Subunit Alpha Cav1.1 protein
CACNA1S protein
CACH1 protein
CACN1 protein
CACNL1A3 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP005032 Human PSMC6 protein (Recombinant) (N-His) (STJP005032) E. coli
STJP007552 Human MARCHF8 protein (Recombinant) (N-His) (STJP007552) E. coli
STJP008271 Human TDG protein (Recombinant) (N-His) (STJP008271) E. coli

Related Products

!