Human CACNA1B protein (Recombinant) (N-His) (STJP005115)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CACNA1B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CACNA1B |
| Gene ID | 774 |
| Uniprot ID | CAC1B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp132 |
Additional Info
| Post Translational Modifications | Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. Isoform Alpha-1B-1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. |
| Protein Name | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1bBrain Calcium Channel IiiBiiiCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 |
| Database Links | Reactome: R-HSA-112308 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b proteinBrain Calcium Channel Iii proteinBiii proteinCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5 proteinVoltage-Gated Calcium Channel Subunit Alpha Cav2.2 proteinCACNA1B proteinCACH5 proteinCACNL1A5 protein |
Information sourced from Uniprot.org