Human CACNA1B protein (Recombinant) (N-His) (STJP005115)

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STJP005115
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CACNA1B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CACNA1B
Gene ID: 774
Uniprot ID: CAC1B_HUMAN
Immunogen Region: Met1-Asp132
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. Isoform Alpha-1B-1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents.
Protein Name Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b
Brain Calcium Channel Iii
Biii
Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 5
Voltage-Gated Calcium Channel Subunit Alpha Cav2.2
Database Links Reactome: R-HSA-112308
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b protein
Brain Calcium Channel Iii protein
Biii protein
Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 5 protein
Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 protein
CACNA1B protein
CACH5 protein
CACNL1A5 protein

Information sourced from Uniprot.org

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