| Host: | Mammalian Cells |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human C4orf48-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | NICOL1 |
| Gene ID: | 401115 |
| Uniprot ID: | NICOL_HUMAN |
| Immunogen Region: | Glu35-His95 |
| Immunogen: | Homo sapiens (Human) |
| Function | mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation. Also binds to the 3'-UTR of ACTA2. Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation. |
| Protein Name | Nell2-Interacting Cell Ontogeny Regulator 1Nell2-Interacting Cofactor For Lumicrine SignalingNicol |
| Database Links | |
| Cellular Localisation | SecretedCytoplasmPerinuclear RegionDetected In The Perinuclear Region Of Fibroblasts |
| Alternative Protein Names | Nell2-Interacting Cell Ontogeny Regulator 1 proteinNell2-Interacting Cofactor For Lumicrine Signaling proteinNicol proteinNICOL1 proteinC4orf48 protein |
Information sourced from Uniprot.org