| Tissue Specificity | Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal.lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. |
| Post Translational Modifications | Phosphorylated by PRKDC. |
| Function | Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. |
| Protein Name | Nuclear Nucleic Acid-Binding Protein C1dHc1d |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusCytoplasmNucleolusExosc10 Is Required For Nucleolar LocalizationColocalizes With Tsnax In The Nucleus |
| Alternative Protein Names | Nuclear Nucleic Acid-Binding Protein C1d proteinHc1d proteinC1D protein |
Information sourced from Uniprot.org
