Human BTLA/CD272 protein (Recombinant) (C-His&Avi) {Biotin} (STJP020235)

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STJP020235-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Biotin
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: BTLA
Gene ID: 151888
Uniprot ID: BTLA_HUMAN
Immunogen Region: Lys31-Ser150
Immunogen: Biotinylated Recombinant Human BTLA/CD272 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Lys31-Ser150) of Human BTLA/CD272 fused with His tag and Avi tag at the C-terminus.
Post Translational Modifications Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
Function Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Protein Name B- And T-Lymphocyte Attenuator
B- And T-Lymphocyte-Associated Protein
Cd Antigen Cd272
Database Links Reactome: R-HSA-9927353
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names B- And T-Lymphocyte Attenuator protein
B- And T-Lymphocyte-Associated Protein protein
Cd Antigen Cd272 protein
BTLA protein

Information sourced from Uniprot.org

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