| Post Translational Modifications | Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX. |
| Function | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells.as well as in signal transduction in endocardial and arterial endothelial cells. |
| Protein Name | Cytoplasmic Tyrosine-Protein Kinase BmxBone Marrow Tyrosine Kinase Gene In Chromosome X ProteinEpithelial And Endothelial Tyrosine KinaseEtkNtk38 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-1660499 |
| Cellular Localisation | CytoplasmLocalizes To The Edges Of Spreading Cells When Complexed With Bcar1 |
| Alternative Protein Names | Cytoplasmic Tyrosine-Protein Kinase Bmx proteinBone Marrow Tyrosine Kinase Gene In Chromosome X Protein proteinEpithelial And Endothelial Tyrosine Kinase proteinEtk proteinNtk38 proteinBMX protein |
Information sourced from Uniprot.org
