Human BMPR2 protein (Recombinant-Active) (C-His) (STJP012106)

Name: Human BMPR2 protein (Recombinant-Active) (C-His) (STJP012106)
SKU: STJP012106-100
Price: 604.2 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP012106-100

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Short Description	Recombinant-Active-Human BMPR2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Immobilised human BMPR2 at 1 Mu g/mL (100 Mu L/well) can bind human BMP2 with a linear range of 0.015-7.4 Mu g/ml.

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA.
Protein Name	Bone Morphogenetic Protein Receptor Type-2 Bmp Type-2 Receptor Bmpr-2 Bone Morphogenetic Protein Receptor Type Ii Bmp Type Ii Receptor Bmpr-Ii
Database Links	Reactome: R-HSA-201451
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Bone Morphogenetic Protein Receptor Type-2 protein Bmp Type-2 Receptor protein Bmpr-2 protein Bone Morphogenetic Protein Receptor Type Ii protein Bmp Type Ii Receptor protein Bmpr-Ii protein BMPR2 protein PPH1 protein

Information sourced from Uniprot.org