Human BMP7 protein (Recombinant-Active) (tag free) (STJP012499)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human BMP7-tag free protein was developed from mammalian cells and has a target region of tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.2 Mu m filtered solution in 20 mM PB, 100 mM NaCl, 5% Mannitol, 0.05% Tween 80, pH 7.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | BMP7 |
| Gene ID | 655 |
| Uniprot ID | BMP7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser293-His431 |
Additional Info
| Post Translational Modifications | Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. |
| Function | Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Promotes the expression of HAMP, this is repressed by its interaction with ERFE. |
| Protein Name | Bone Morphogenetic Protein 7Bmp-7Osteogenic Protein 1Op-1Eptotermin Alfa |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-9844594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Bone Morphogenetic Protein 7 proteinBmp-7 proteinOsteogenic Protein 1 proteinOp-1 proteinEptotermin Alfa proteinBMP7 proteinOP1 protein |
Information sourced from Uniprot.org