Human BMP10 protein (Recombinant) (N-GST) (STJP003426)

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STJP003426
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BMP10-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BMP10
Gene ID: 27302
Uniprot ID: BMP10_HUMAN
Immunogen Region: Arg315-Arg424
Immunogen: Homo sapiens (Human)
Function Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Protein Name Bone Morphogenetic Protein 10
Bmp-10
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-2129379
Cellular Localisation Secreted
Alternative Protein Names Bone Morphogenetic Protein 10 protein
Bmp-10 protein
BMP10 protein

Information sourced from Uniprot.org

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