| Post Translational Modifications | Glycosylated at Asn-454. Glycosylation is crucial for recognition by the activin receptor type I/ACVR1. |
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression. |
| Protein Name | Bone Morphogenetic Protein 6Bmp-6Vg-1-Related ProteinVg-1-RVgr-1 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Bone Morphogenetic Protein 6 proteinBmp-6 proteinVg-1-Related Protein proteinVg-1-R proteinVgr-1 proteinBMP6 proteinVGR protein |
Information sourced from Uniprot.org
