| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level). |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 2Bloc-1 Subunit 2Centrosome-Associated Protein |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLysosome MembraneLocalizes To The Centrosomes In A Microtubule-Dependent Manner |
| Alternative Protein Names | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 2 proteinBloc-1 Subunit 2 proteinCentrosome-Associated Protein proteinBLOC1S2 proteinBLOS2 proteinCEAP protein |
Information sourced from Uniprot.org
