| Host: | E.coli |
| Applications: | SDS-PAGE/Enzyme Activity |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Bleomycin Hydrolase/BLMH-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Specific activity: > 2, 500pmol/min/ug, and is defined as the amount of enzyme that hydrolyze 1pmole of Met-AMC to Methionine and AMC per minute at pH7.5 at 37C. |
| Gene Symbol: | BLMH |
| Gene ID: | 642 |
| Uniprot ID: | BLMH_HUMAN |
| Immunogen Region: | 1-455aa |
| Accession Number: | NP_000377 |
| Immunogen: | Human |
| Immunogen Sequence: |
| Function | The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. |
| Protein Name | Bleomycin HydrolaseBhBlm HydrolaseBmh |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoplasmic GranuleCo-Localizes With Nudt12 In The Cytoplasmic Granules |
| Alternative Protein Names | Bleomycin Hydrolase proteinBh proteinBlm Hydrolase proteinBmh proteinBLMH protein |
Information sourced from Uniprot.org
