Human BIN1 protein (Recombinant) (N-His) (STJP003158)

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STJP003158
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BIN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BIN1
Gene ID: 274
Uniprot ID: BIN1_HUMAN
Immunogen Region: Met1-Ser276
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by protein kinase C.
Function Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
Protein Name Myc Box-Dependent-Interacting Protein 1
Amphiphysin Ii
Amphiphysin-Like Protein
Box-Dependent Myc-Interacting Protein 1
Bridging Integrator 1
Database Links Reactome: R-HSA-8856828
Cellular Localisation Isoform Bin1: Nucleus
Cytoplasm
Endosome
Cell Membrane
Sarcolemma
T-Tubule
Isoform Iia: Cytoplasm
Alternative Protein Names Myc Box-Dependent-Interacting Protein 1 protein
Amphiphysin Ii protein
Amphiphysin-Like Protein protein
Box-Dependent Myc-Interacting Protein 1 protein
Bridging Integrator 1 protein
BIN1 protein
AMPHL protein

Information sourced from Uniprot.org

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