Human BDNF (Neurotrophic Factor Bdnf Precursor Form) Antibody Pair (STJAP00012)

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STJAP00012-50
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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This BDNF antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: BDNF
Gene ID: 627
Uniprot ID: BDNF_HUMAN
Immunogen: Capture immunogen: Recombinant Human BDNF protein.
Detection Immunogen: Recombinant Human BDNF protein.
Post Translational Modifications Neurotrophic factor BDNF precursor form: N-glycosylated and glycosulfated, contrary to mature BDNF. Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
Function Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Neurotrophic factor BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
Protein Name Neurotrophic Factor Bdnf Precursor Form
Probdnf
Abrineurin
Brain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-6811558
Reactome: R-HSA-9022702
Reactome: R-HSA-9024909
Reactome: R-HSA-9026519
Reactome: R-HSA-9026527
Reactome: R-HSA-9028335
Reactome: R-HSA-9028731
Reactome: R-HSA-9032500
Reactome: R-HSA-9032759
Reactome: R-HSA-9032845
Reactome: R-HSA-9768919
Cellular Localisation Secreted
Neurotrophic Factor Bdnf Precursor Form: Secreted
A Proportion Of Bdnf Is Secreted As Immature Precursor (Probdnf)
Alternative Antibody Pair Names Neurotrophic Factor Bdnf Precursor Form antibody pair
Probdnf antibody pair
Abrineurin antibody pair
Brain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf antibody pair
BDNF antibody pair

Information sourced from Uniprot.org