Human BCAR1 protein (Recombinant) (N-His) (STJP004987)

SKU:
STJP004987
€410.63 - €1,796.88
Free Shipping
Processing The item has been added

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BCAR1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BCAR1
Gene ID: 9564
Uniprot ID: BCAR1_HUMAN
Immunogen Region: Met1-Leu240
Immunogen: Homo sapiens (Human)
Post Translational Modifications PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif.phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix. Dephosphorylated by PTPN14 at Tyr-128. Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner.phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway.
Function Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling.
Protein Name Breast Cancer Anti-Estrogen Resistance Protein 1
Crk-Associated Substrate
Cas Scaffolding Protein Family Member 1
P130cas
Database Links Reactome: R-HSA-186763
Reactome: R-HSA-372708
Reactome: R-HSA-4420097
Reactome: R-HSA-8849471
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cell Projection
Axon
Unphosphorylated Form Localizes In The Cytoplasm
Localizes To Focal Adhesion Sites Following Integrin Engagement
Alternative Protein Names Breast Cancer Anti-Estrogen Resistance Protein 1 protein
Crk-Associated Substrate protein
Cas Scaffolding Protein Family Member 1 protein
P130cas protein
BCAR1 protein
CAS protein
CASS1 protein
CRKAS protein

Information sourced from Uniprot.org