Human BCAM/CD239 protein (Recombinant) (C-His) (STJP019892)

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STJP019892-100
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Covered by St John's Laboratory Guarantee

Host:HEK293 cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:< 1 EU/Mu g of the protein by LAL method.
Gene Symbol:BCAM
Gene ID:4059
Uniprot ID:BCAM_HUMAN
Immunogen:Recombinant Human BCAM/CD239 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu32-Ala547) of Human BCAM/CD239 (Accession #P50895) fused with a C-His tag at the C-terminus.
Immunogen Region:Glu32-Ala547
Immunogen Sequence:EVRLSVPPLVEVMRGKSVIL DCTPTGTHDHYMLEWFLTDR SGARPRLASAEMQGSELQVT MHDTRGRSPPYQLDSQGRLV LAEAQVGDERDYVCVVRAGA AGTAEATARLNVFAKPEATE VSPNKGTLSVMEDSAQEIAT CNSRNGNPAPKITWYRNGQR LEVPVEMNPEGYMTSRTVRE ASGLLSLTSTLYLRLRKDDR DASFHCAAHYSLPEGRHGRL DSPTFHLTLHYPTEHVQFW
Tissue Specificity Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
Post Translational Modifications Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1.
Function Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.
Protein Name Basal Cell Adhesion Molecule
Auberger B Antigen
B-Cam Cell Surface Glycoprotein
F8/G253 Antigen
Lutheran Antigen
Lutheran Blood Group Glycoprotein
Cd Antigen Cd239
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Basal Cell Adhesion Molecule protein
Auberger B Antigen protein
B-Cam Cell Surface Glycoprotein
F8/G253 Antigen protein
Lutheran Antigen protein
Lutheran Blood Group Glycoprotein
Cd Antigen Cd239 protein
BCAM protein
LU protein
MSK19 protein

Information sourced from Uniprot.org

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