• Human Basigin/CD147 protein (Recombinant) (C-hFc&His) (STJP000880)
  • Human Basigin/CD147 protein (Recombinant) (C-hFc&His) (STJP000880)
  • Human Basigin/CD147 protein (Recombinant) (C-hFc&His) (STJP000880)
  • Human Basigin/CD147 protein (Recombinant) (C-hFc&His) (STJP000880)

Human Basigin/CD147 protein (Recombinant) (C-hFc&His) (STJP000880)

SKU:
STJP000880

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Basigin/CD147-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CD147 at 1 Mu g/mL (100 Mu L/well) can bind CD147 Mouse mAb with a linear range of 0.12-3.05 ng/ml.
Gene Symbol: BSG
Gene ID: 682
Uniprot ID: BASI_HUMAN
Immunogen: Recombinant Human Basigin/CD147 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr25-His205) of human CD147/EMMPRIN/Basigin (Accession #NP_001719.2) fused with an Fc, 6Ă—His tag at the C-terminus.
Tissue Specificity Isoform 1: Retina-specific. Expressed in retinal cone photoreceptors (at protein level). Isoform 2: Expressed in erythrocytes (at protein level). Highly expressed in melanoma cell lines (at protein level). Highly expressed in the heart, kidney, skeletal muscle and testis. Isoform 3: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus. Isoform 4: Highly expressed in the bone marrow, fetal liver, lung, testis and thymus.
Post Translational Modifications Isoform 2: N-glycosylated. Isoform 3: N-glycosylated. Isoform 4: N-glycosylated.
Function Isoform 1: Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes. Isoform 1: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. Isoform 2: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells. Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells). Isoform 2: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3. Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte. This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion. Isoform 2: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. Isoform 2: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. Isoform 2: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. Isoform 2: (Microbial infection) Acts as a receptor for measles virus. Isoform 2: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells.
Protein Name Basigin
5f7
Collagenase Stimulatory Factor
Extracellular Matrix Metalloproteinase Inducer
Emmprin
Hepatoma-Associated Antigen
Hab18g
Leukocyte Activation Antigen M6
Ok Blood Group Antigen
Tumor Cell-Derived Collagenase Stimulatory Factor
Tcsf
Cd Antigen Cd147
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-210991
Reactome: R-HSA-216083
Reactome: R-HSA-433692
Reactome: R-HSA-5619070
Reactome: R-HSA-70268
Reactome: R-HSA-9749641
Cellular Localisation Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Photoreceptor Inner Segment
Cell Projection
Cilium
Photoreceptor Outer Segment
Isoform 2: Cell Membrane
Endosome
Endoplasmic Reticulum Membrane
Basolateral Cell Membrane
Isoform 3: Cell Membrane
Isoform 4: Cell Membrane
Alternative Protein Names Basigin protein
5f7 protein
Collagenase Stimulatory Factor protein
Extracellular Matrix Metalloproteinase Inducer protein
Emmprin protein
Hepatoma-Associated Antigen protein
Hab18g protein
Leukocyte Activation Antigen M6 protein
Ok Blood Group Antigen protein
Tumor Cell-Derived Collagenase Stimulatory Factor protein
Tcsf protein
Cd Antigen Cd147 protein
BSG protein
UNQ6505 protein
PRO21383 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance