Human BAG5 protein (Recombinant) (N-His) (STJP006365)

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STJP006365
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BAG5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BAG5
Gene ID: 9529
Uniprot ID: BAG5_HUMAN
Immunogen Region: Met1-Asp248
Immunogen: Homo sapiens (Human)
Function Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN.
Protein Name Bag Family Molecular Chaperone Regulator 5
Bag-5
Bcl-2-Associated Athanogene 5
Database Links Reactome: R-HSA-3371453
Cellular Localisation In Cardiomyocytes
Localized At Specialized Membrane Contact Sites Between T-Tubules And The Sarcoplasmic Reticulum
Known As Junctional Membrane Complexes
Alternative Protein Names Bag Family Molecular Chaperone Regulator 5 protein
Bag-5 protein
Bcl-2-Associated Athanogene 5 protein
BAG5 protein
KIAA0873 protein

Information sourced from Uniprot.org

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