Function | Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. |
Protein Name | Bag Family Molecular Chaperone Regulator 5Bag-5Bcl-2-Associated Athanogene 5 |
Database Links | Reactome: R-HSA-3371453 |
Cellular Localisation | In CardiomyocytesLocalized At Specialized Membrane Contact Sites Between T-Tubules And The Sarcoplasmic ReticulumKnown As Junctional Membrane Complexes |
Alternative Protein Names | Bag Family Molecular Chaperone Regulator 5 proteinBag-5 proteinBcl-2-Associated Athanogene 5 proteinBAG5 proteinKIAA0873 protein |
Information sourced from Uniprot.org