| Tissue Specificity | Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues. |
| Post Translational Modifications | At the cell surface, may be cleaved by MMP14. N-glycosylated. |
| Function | Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. |
| Protein Name | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell ActivationPlatelet Receptor Gi24Stress-Induced Secreted Protein-1Sisp-1V-Set Domain-Containing Immunoregulatory ReceptorV-Set Immunoregulatory Receptor |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation proteinPlatelet Receptor Gi24 proteinStress-Induced Secreted Protein-1 proteinSisp-1 proteinV-Set Domain-Containing Immunoregulatory Receptor proteinV-Set Immunoregulatory Receptor proteinVSIR proteinC10orf54 proteinSISP1 proteinVISTA proteinPP2135 proteinUNQ730 proteinPRO1412 protein |
Information sourced from Uniprot.org
