Human B7-H3/CD276 protein (Recombinant) (C-His) (STJP002683)

SKU:
STJP002683

£76.50 - £357.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human B7-H3/CD276-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human B7-H3 at 2 Mu g/mL (100 Mu L/well) can bind Anti-Human B7-H3 Antibody with a linear range of 1-4 ng/mL.
Gene Symbol: CD276
Gene ID: 80381
Uniprot ID: CD276_HUMAN
Immunogen Region: Leu29-Pro245
Immunogen: Recombinant Human B7-H3/CD276 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu29-Pro245) of human B7-H3 (Accession #NP_079516) fused with a 6×His tag at the C-terminus.
Function May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Protein Name Cd276 Antigen
4ig-B7-H3
B7 Homolog 3
B7-H3
Costimulatory Molecule
Cd Antigen Cd276
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Cd276 Antigen protein
4ig-B7-H3 protein
B7 Homolog 3 protein
B7-H3 protein
Costimulatory Molecule protein
Cd Antigen Cd276 protein
CD276 protein
B7H3 protein
PSEC0249 protein
UNQ309 protein
PRO352 protein

Information sourced from Uniprot.org

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