| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human B7-H3/CD276-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human CD276 at 2 Mu g/mL (100 Mu L/well) can bind CD276 Rabbit pAb with a linear range of 0.1-152 ng/mL. |
| Gene Symbol: |
CD276 |
| Gene ID: |
80381 |
| Uniprot ID: |
CD276_HUMAN |
| Immunogen: |
Recombinant Human B7-H3/CD276 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu29-Pro245) of human B7-H3/CD276 (Accession #NP_079516) fused with a Fc, 6×His tag at the C-terminus. |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen4ig-B7-H3B7 Homolog 3B7-H3Costimulatory MoleculeCd Antigen Cd276 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd276 Antigen protein4ig-B7-H3 proteinB7 Homolog 3 proteinB7-H3 proteinCostimulatory Molecule proteinCd Antigen Cd276 proteinCD276 proteinB7H3 proteinPSEC0249 proteinUNQ309 proteinPRO352 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
