Name: Human B7-H3/CD276 protein (Recombinant) (C-hFc&His) (STJP001363)
SKU: STJP001363
Availability: InStock

Human B7-H3/CD276 protein (Recombinant) (C-hFc&His) (STJP001363)

SKU:

STJP001363

£97.50 - £359.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human CD276 at 2 Mu g/mL (100 Mu L/well) can bind CD276 Rabbit pAb with a linear range of 0.1-152 ng/mL.

Gene Symbol:	CD276
Gene ID:	80381
Uniprot ID:	CD276_HUMAN
Immunogen:	Recombinant Human B7-H3/CD276 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu29-Pro245) of human B7-H3/CD276 (Accession #NP_079516) fused with a Fc, 6×His tag at the C-terminus.
Immunogen Sequence:	LEVQVPEDPVVALVGTDATL CCSFSPEPGFSLAQLNLIWQ LTDTKQLVHSFAEGQDQGSA YANRTALFPDLLAQGNASLR LQRVRVADEGSFTCFVSIRD FGSAAVSLQVAAPYSKPSMT LEPNKDLRPGDTVTITCSSY RGYPEAEVFWQDGQGVPLTG NVTTSQMANEQGLFDVHSVL RVVLGANGTYSCLVRNPVLQ QDAHGSVTITGQPMTFP

Function	May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Protein Name	Cd276 Antigen 4ig-B7-H3 B7 Homolog 3 B7-H3 Costimulatory Molecule Cd Antigen Cd276
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Cd276 Antigen protein 4ig-B7-H3 protein B7 Homolog 3 protein B7-H3 protein Costimulatory Molecule protein Cd Antigen Cd276 protein CD276 protein B7H3 protein PSEC0249 protein UNQ309 protein PRO352 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002683	Human B7-H3/CD276 protein (Recombinant) (C-His) (STJP002683)	HEK293 cells
STJP001100	Human B7-H5/Gi24/VISTA protein (Recombinant) (C-hFc&His) (STJP001100)	HEK293 cells
STJP002876	Mouse CD276 protein (Recombinant) (C-hFc) (STJP002876)	HEK293 cells
STJP000958	Human B7-H1/PD-L1/CD274 protein (Recombinant) (C-hFc&His) (STJP000958)	HEK293 cells
STJP002677	Human B7-DC/PD-L2/CD273 protein (Recombinant) (C-hFc & His) (STJP002677)	HEK293 cells
STJP002738	Mouse B7-1/CD80 protein (Recombinant) (C-hFc & His) (STJP002738)	HEK293 cells
STJP001744	Human B7-H3 (4Ig) /B7-H3b protein (Recombinant) (C-His-Avi) {Biotin} (STJP001744)	HEK293

Human B7-H3/CD276 protein (Recombinant) (C-hFc&His) (STJP001363)