Human B4GALNT2 protein (Recombinant) (N-His) (STJP006398)

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STJP006398
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human B4GALNT2-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: B4GALNT2
Gene ID: 124872
Uniprot ID: B4GN2_HUMAN
Immunogen Region: Thr324-Ala566
Immunogen: Homo sapiens (Human)
Function Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells.
Protein Name Beta-1 -4 N-Acetylgalactosaminyltransferase 2
Sd(A Beta-1 -4-Galnac Transferase
Udp-Galnac -Neu5aca2-3galb-R B1 -4-N-Acetylgalactosaminyltransferase
Database Links Reactome: R-HSA-446203
Reactome: R-HSA-9037629
Cellular Localisation Isoform 1: Golgi Apparatus
Trans-Golgi Network Membrane
Single-Pass Type Ii Membrane Protein
Cytoplasmic Vesicle Membrane
Partially Colocalizes With Eea1 And Lamp2 In Early Endosomes And Lysosomes
Respectively
Isoform 2: Golgi Apparatus
Alternative Protein Names Beta-1 -4 N-Acetylgalactosaminyltransferase 2 protein
Sd(A Beta-1 -4-Galnac Transferase protein
Udp-Galnac -Neu5aca2-3galb-R B1 -4-N-Acetylgalactosaminyltransferase protein
B4GALNT2 protein
GALGT2 protein

Information sourced from Uniprot.org

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