Human B3GAT3 protein (Recombinant) (His-Tag) (STJP018221)

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STJP018221
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human B3GAT3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: B3GAT3
Gene ID: 26229
Uniprot ID: B3GA3_HUMAN
Immunogen Region: 29-335aa
Accession Number: NP_036332
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSQPCDCLP PLRAAAEQLR QKDLRISQLQ AELRRPPPAP AQPPEPEALP TIYVVTPTYA RLVQKAELVR LSQTLSLVPR LHWLLVEDAE GPTPLVSGLL AASGLLFTHL VVLTPKAQRL REGEPGWVHP RGVEQRNKAL DWLRGRGGAV GGEKDPPPPG TQGVVYFADD DNTYSRELFE EMRWTRGVSV WPVGLVGGLR FEGPQVQD
Tissue Specificity Ubiquitous (but weakly expressed in all tissues examined).
Post Translational Modifications N-glycosylated.
Function Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation.
Protein Name Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3
Beta-1 -3-Glucuronyltransferase 3
Glucuronosyltransferase I
Glcat-I
Udp-Glcua -Gal Beta-1 -3-Gal-R Glucuronyltransferase
Glcuat-I
Database Links Reactome: R-HSA-1971475
Reactome: R-HSA-3560801
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Golgi Apparatus
Cis-Golgi Network
Alternative Protein Names Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3 protein
Beta-1 -3-Glucuronyltransferase 3 protein
Glucuronosyltransferase I protein
Glcat-I protein
Udp-Glcua -Gal Beta-1 -3-Gal-R Glucuronyltransferase protein
Glcuat-I protein
B3GAT3 protein

Information sourced from Uniprot.org

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