Human AZIN1 protein (Recombinant) (N-His) (STJP003212)

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STJP003212
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AZIN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AZIN1
Gene ID: 51582
Uniprot ID: AZIN1_HUMAN
Immunogen Region: Ile5-Lys290
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizyme OAZ1.
Function Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
Protein Name Antizyme Inhibitor 1
Azi
Azi1
Ornithine Decarboxylase Antizyme Inhibitor
Database Links Reactome: R-HSA-350562
Cellular Localisation Nucleus
Alternative Protein Names Antizyme Inhibitor 1 protein
Azi protein
Azi1 protein
Ornithine Decarboxylase Antizyme Inhibitor protein
AZIN1 protein
OAZI protein
OAZIN protein

Information sourced from Uniprot.org

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