Human ATXN7 protein (Recombinant) (N-GST & C-His) (STJP008492)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATXN7-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATXN7 |
| Gene ID | 6314 |
| Uniprot ID | ATX7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp342-His401 |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-7 (CASP7). The cleavage may be involved in SCA7 degeneration: the isoform fragments may exert distinct toxic influences that could contribute to selective neurodegeneration. Sumoylation decreases the aggregation propensity and cellular toxicity of forms with an expanded poly-Gln region but has no effect on subcellular location or interaction with components of the STAGA complex. |
| Function | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex. Necessary for microtubule cytoskeleton stabilization. Involved in neurodegeneration. |
| Protein Name | Ataxin-7Spinocerebellar Ataxia Type 7 Protein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-5689880 |
| Cellular Localisation | Isoform A: NucleusNucleusNucleolusNucleus MatrixCytoplasmCytoskeletonIn Addition To A Diffuse Distribution Throughout The NucleusIt Is Associated With The Nuclear Matrix And The NucleolusIt Is Able To Shuttle Between The Nucleus And CytoplasmIsoform B: Cytoplasm |
| Alternative Protein Names | Ataxin-7 proteinSpinocerebellar Ataxia Type 7 Protein proteinATXN7 proteinSCA7 protein |
Information sourced from Uniprot.org