Human ATXN7 protein (Recombinant) (N-GST & C-His) (STJP008492)

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STJP008492
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ATXN7-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ATXN7
Gene ID: 6314
Uniprot ID: ATX7_HUMAN
Immunogen Region: Asp342-His401
Immunogen: Homo sapiens (Human)
Post Translational Modifications Proteolytically cleaved by caspase-7 (CASP7). The cleavage may be involved in SCA7 degeneration: the isoform fragments may exert distinct toxic influences that could contribute to selective neurodegeneration. Sumoylation decreases the aggregation propensity and cellular toxicity of forms with an expanded poly-Gln region but has no effect on subcellular location or interaction with components of the STAGA complex.
Function Acts as a component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.
Protein Name Ataxin-7
Spinocerebellar Ataxia Type 7 Protein
Database Links Reactome: R-HSA-3214847
Reactome: R-HSA-5689880
Cellular Localisation Isoform A: Nucleus
Nucleus
Nucleolus
Nucleus Matrix
Cytoplasm
Cytoskeleton
In Addition To A Diffuse Distribution Throughout The Nucleus
It Is Associated With The Nuclear Matrix And The Nucleolus
It Is Able To Shuttle Between The Nucleus And Cytoplasm
Isoform B: Cytoplasm
Alternative Protein Names Ataxin-7 protein
Spinocerebellar Ataxia Type 7 Protein protein
ATXN7 protein
SCA7 protein

Information sourced from Uniprot.org

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