Human ATP8A1 protein (Recombinant) (N-His) (STJP015867)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATP8A1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ATP8A1 |
| Gene ID | 10396 |
| Uniprot ID | AT8A1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu119-Arg292 |
Additional Info
| Post Translational Modifications | Cleaved by calpain in a caspase- and calcium influx-dependent manner during platelet apoptosis leading to a 100 kDa polypeptide. |
| Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane. Acts as aminophospholipid translocase at the cell membrane in neuronal cells. |
| Protein Name | Phospholipid-Transporting Atpase IaAtpase Class I Type 8a Member 1Chromaffin Granule Atpase IiP4-Atpase Flippase Complex Alpha Subunit Atp8a1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-936837 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleChromaffin Granule MembraneMulti-Pass Membrane ProteinCytoplasmic GranuleCell MembraneEndoplasmic ReticulumGolgi ApparatusExit From The Endoplasmic Reticulum Requires The Presence Of Tmem30aBut Not Tmem30bIn The Presence Of Tmem30aPredominantly Located In Cytoplasmic Punctate Structures And Localizes To The Cell MembraneLocalizes To Plasma Membranes Of Red Blood Cells |
| Alternative Protein Names | Phospholipid-Transporting Atpase Ia proteinAtpase Class I Type 8a Member 1 proteinChromaffin Granule Atpase Ii proteinP4-Atpase Flippase Complex Alpha Subunit Atp8a1 proteinATP8A1 proteinATPIA protein |
Information sourced from Uniprot.org