| Function | Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex. |
| Protein Name | Atp Synthase F(1 Complex Subunit Epsilon - MitochondrialAtpase Subunit EpsilonAtp Synthase F1 Subunit Epsilon |
| Database Links | Reactome: R-HSA-163210Reactome: R-HSA-8949613 |
| Cellular Localisation | MitochondrionMitochondrion Inner Membrane |
| Alternative Protein Names | Atp Synthase F(1 Complex Subunit Epsilon - Mitochondrial proteinAtpase Subunit Epsilon proteinAtp Synthase F1 Subunit Epsilon proteinATP5F1E proteinATP5E protein |
Information sourced from Uniprot.org
