| Tissue Specificity | Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle. |
| Post Translational Modifications | |
| Function | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk. |
| Protein Name | Plasma Membrane Calcium-Transporting Atpase 2Pmca2Plasma Membrane Calcium Atpase Isoform 2Plasma Membrane Calcium Pump Isoform 2 |
| Database Links | Reactome: R-HSA-418359Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9662360 Q01814-2Reactome: R-HSA-9662361 Q01814-2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSynapseIsoform Wa: Apical Cell MembraneBasolateral Cell MembraneIsoform Wb: Apical Cell MembraneIsoform Xb: Basolateral Cell MembraneIsoform Za: Basolateral Cell MembraneIsoform Zb: Basolateral Cell Membrane |
| Alternative ELISA Names | Plasma Membrane Calcium-Transporting Atpase 2 ELISA kitPmca2 ELISA kitPlasma Membrane Calcium Atpase Isoform 2 ELISA kitPlasma Membrane Calcium Pump Isoform 2 ELISA kitATP2B2 ELISA kitPMCA2 ELISA kit |
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Information sourced from Uniprot.org
