Human ATP10A protein (Recombinant) (N-His) (STJP010696)

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STJP010696
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ATP10A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ATP10A
Gene ID: 57194
Uniprot ID: AT10A_HUMAN
Immunogen Region: Glu688-Arg866
Immunogen: Homo sapiens (Human)
Post Translational Modifications Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.
Function Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).
Protein Name Phospholipid-Transporting Atpase Va
Atpase Class V Type 10a
Aminophospholipid Translocase Va
P4-Atpase Flippase Complex Alpha Subunit Atp10a
Database Links Reactome: R-HSA-936837
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Exit From The Endoplasmic Reticulum Requires The Presence Of Tmem30a
But Not That Of Tmem30b
Alternative Protein Names Phospholipid-Transporting Atpase Va protein
Atpase Class V Type 10a protein
Aminophospholipid Translocase Va protein
P4-Atpase Flippase Complex Alpha Subunit Atp10a protein
ATP10A protein
ATP10C protein
ATPVA protein
ATPVC protein
KIAA0566 protein

Information sourced from Uniprot.org

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