| Post Translational Modifications | Acetylated by EP300. Polyubiquitinated on Lys-45 via 'Lys-63'-linked ubiquitin by TRIM32.this modification positiely regulates ATG8 and ATG12 activating enzyme activity leading to initiation of autophagy under metabolic stress. |
| Function | E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner. |
| Protein Name | Ubiquitin-Like Modifier-Activating Enzyme Atg7Atg12-Activating Enzyme E1 Atg7Autophagy-Related Protein 7Apg7-LikeHagp7Ubiquitin-Activating Enzyme E1-Like Protein |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-6798695Reactome: R-HSA-6802952Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmPreautophagosomal StructureLocalizes Also To Discrete Punctae Along The Ciliary Axoneme And To The Base Of The Ciliary Axoneme |
| Alternative Protein Names | Ubiquitin-Like Modifier-Activating Enzyme Atg7 proteinAtg12-Activating Enzyme E1 Atg7 proteinAutophagy-Related Protein 7 proteinApg7-Like proteinHagp7 proteinUbiquitin-Activating Enzyme E1-Like Protein proteinATG7 proteinAPG7L protein |
Information sourced from Uniprot.org
