Human ATG13 protein (Recombinant) (N-His) (STJP009583)

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STJP009583
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ATG13-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ATG13
Gene ID: 9776
Uniprot ID: ATG13_HUMAN
Immunogen Region: Asp57-Arg190
Immunogen: Homo sapiens (Human)
Function Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
Protein Name Autophagy-Related Protein 13
Database Links Reactome: R-HSA-1632852
Cellular Localisation Cytoplasm
Cytosol
Preautophagosomal Structure
Under Starvation Conditions
Is Localized To Puncate Structures Primarily Representing The Isolation Membrane
The Isolation Membrane Sequesters A Portion Of The Cytoplasm Resulting In Autophagosome Formation
Alternative Protein Names Autophagy-Related Protein 13 protein
ATG13 protein
KIAA0652 protein

Information sourced from Uniprot.org