Human Ataxin-3 protein (Recombinant) (No-Tag) (STJP016487)

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STJP016487
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Ataxin-3-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 50mM NaCl, 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: ATXN3
Gene ID: 4287
Uniprot ID: ATX3_HUMAN
Immunogen Region: 1-370aa
Accession Number: AAH33711
Immunogen: Human
Immunogen Sequence: MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEED
Tissue Specificity Ubiquitous.
Post Translational Modifications Monoubiquitinated N-terminally by UBE2W, possibly leading to activate the deubiquitinating enzyme activity.
Function Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription. Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex. Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1.
Protein Name Ataxin-3
Machado-Joseph Disease Protein 1
Spinocerebellar Ataxia Type 3 Protein
Database Links Reactome: R-HSA-5689877
Reactome: R-HSA-9615017
Cellular Localisation Nucleus Matrix
Nucleus
Lysosome Membrane
Peripheral Membrane Protein
Predominantly Nuclear
But Not Exclusively
Inner Nuclear Matrix
Recruited To Lysosomal Membrane In Response To Amino Acid Deprivation By The Raga/Rraga-Ragb/Rragb Complex
Alternative Protein Names Ataxin-3 protein
Machado-Joseph Disease Protein 1 protein
Spinocerebellar Ataxia Type 3 Protein protein
ATXN3 protein
ATX3 protein
MJD protein
MJD1 protein
SCA3 protein

Information sourced from Uniprot.org

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