Human ARHGEF15 protein (Recombinant) (N-His) (STJP016355)

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STJP016355
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Short Description :Recombinant-Human ARHGEF15-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:ARHGEF15
Gene ID:22899
Uniprot ID:ARHGF_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Arg619-Thr741
Post Translational Modifications Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination. Ubiquitinated.UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation.
Function Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
Protein Name Rho Guanine Nucleotide Exchange Factor 15
Ephexin-5
E5
Vsm-Rhogef
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Cellular Localisation Cell Projection
Dendrite
Expressed Exclusively In Dendrites Of The Developing Hippocampus
Alternative Protein Names Rho Guanine Nucleotide Exchange Factor 15 protein
Ephexin-5 protein
E5 protein
Vsm-Rhogef protein
ARHGEF15 protein
KIAA0915 protein

Information sourced from Uniprot.org

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