| Post Translational Modifications | Phosphorylated. Phosphorylated in vitro by constitutive active PKN3. |
| Function | GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. |
| Protein Name | Rho Gtpase-Activating Protein 10Gtpase Regulator Associated With Focal Adhesion Kinase 2Graf2Graf-Related Protein 2Rho-Type Gtpase-Activating Protein 10 |
| Database Links | Reactome: R-HSA-211728Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell MembraneEndosome MembraneAssociation To Cell Membrane Is Dependent On Ph DomainColocalized With Mical1Rab8aRab8b And Rab10 On Endosomal Tubules |
| Alternative Protein Names | Rho Gtpase-Activating Protein 10 proteinGtpase Regulator Associated With Focal Adhesion Kinase 2 proteinGraf2 proteinGraf-Related Protein 2 proteinRho-Type Gtpase-Activating Protein 10 proteinARHGAP10 proteinGRAF2 protein |
Information sourced from Uniprot.org
