Human AQP9 protein (Recombinant) (N-GST) (STJP003265)

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STJP003265
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AQP9-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AQP9
Gene ID: 366
Uniprot ID: AQP9_HUMAN
Immunogen Region: Tyr125-Leu158
Immunogen: Homo sapiens (Human)
Function Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis. It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium.
Protein Name Aquaporin-9
Aqp-9
Aquaglyceroporin-9
Small Solute Channel 1
Database Links Reactome: R-HSA-432030
Reactome: R-HSA-432047
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Functions At The Hepatocyte Basolateral Membrane
Alternative Protein Names Aquaporin-9 protein
Aqp-9 protein
Aquaglyceroporin-9 protein
Small Solute Channel 1 protein
AQP9 protein
SSC1 protein

Information sourced from Uniprot.org