| Tissue Specificity | Widely expressed.detected in liver, kidney and lymph node (at protein level). Isoform 1 is highly expressed in the cerebral cortex and cerebellum, compared to isoform 2 (at protein level). Widely expressed.detected throughout the brain, in liver, kidney, skeletal muscle, fibroblasts, lymphocytes and pancreas. |
| Function | DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA). |
| Protein Name | AprataxinForkhead-Associated Domain Histidine Triad-Like ProteinFha-Hit |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmNucleolusUpon Genotoxic StressColocalizes With Xrcc1 At Sites Of Dna DamageColocalizes With Mdc1 At Sites Of Dna Double-Strand BreaksInteraction With Ncl Is Required For Nucleolar LocalizationIsoform 12: Cytoplasm |
| Alternative Protein Names | Aprataxin proteinForkhead-Associated Domain Histidine Triad-Like Protein proteinFha-Hit proteinAPTX proteinAXA1 protein |
Information sourced from Uniprot.org
