Human Apolipoprotein C1/APOC1 protein (Recombinant) (His-Tag) (STJP018653)

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STJP018653
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Apolipoprotein C1/APOC1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: APOC1
Gene ID: 341
Uniprot ID: APOC1_HUMAN
Immunogen Region: 27-83aa
Accession Number: NP_001636.1
Immunogen: Human
Immunogen Sequence: TPDVSSA LDKLKEFGNT LEDKARELIS RIKQSELSAK MREWFSETFQ KVKEKLKIDS
Tissue Specificity Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.
Function Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Protein Name Apolipoprotein C-I
Apo-Ci
Apoc-I
Apolipoprotein C1 Cleaved Into - Truncated Apolipoprotein C-I
Database Links Reactome: R-HSA-8866423
Reactome: R-HSA-8964046
Reactome: R-HSA-9029569
Cellular Localisation Secreted
Alternative Protein Names Apolipoprotein C-I protein
Apo-Ci protein
Apoc-I protein
Apolipoprotein C1 Cleaved Into - Truncated Apolipoprotein C-I protein
APOC1 protein

Information sourced from Uniprot.org

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