Human Apolipoprotein A5/APOA5 protein (Recombinant) (His-Tag) (STJP018576)

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STJP018576
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Apolipoprotein A5/APOA5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing, 10% Glycerol, 0.4M urea
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: APOA5
Gene ID: 116519
Uniprot ID: APOA5_HUMAN
Immunogen Region: 24-366aa
Accession Number: NP_443200
Immunogen: Human
Immunogen Sequence: RKGFWDY FSQTSGDKGR VEQIHQQKMA REPATLKDSL EQDLNNMNKF LEKLRPLSGS EAPRLPQDPV GMRRQLQEEL EEVKARLQPY MAEAHELVGW NLEGLRQQLK PYTMDLMEQV ALRVQELQEQ LRVVGEDTKA QLLGGVDEAW ALLQGLQSRV VHHTGRFKEL FHPYAESLVS GIGRHVQELH RSVAPHAPAS PARLSR
Tissue Specificity Liver and plasma.
Post Translational Modifications Phosphorylated by FAM20C in the extracellular medium.
Function Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.
Protein Name Apolipoprotein A-V
Apo-Av
Apoa-V
Apolipoprotein A5
Regeneration-Associated Protein 3
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Reactome: R-HSA-8963889
Reactome: R-HSA-8963901
Cellular Localisation Secreted
Early Endosome
Late Endosome
Golgi Apparatus
Trans-Golgi Network
In The Presence Of Sorl1
Internalized To Early Endosomes
Sorted In A Retrograde Fashion To Late Endosomes
From Which A Portion Is Sent To Lysosomes And Degradation
Another Portion Is Sorted To The Trans-Golgi Network
Alternative Protein Names Apolipoprotein A-V protein
Apo-Av protein
Apoa-V protein
Apolipoprotein A5 protein
Regeneration-Associated Protein 3 protein
APOA5 protein
RAP3 protein
UNQ411 protein
PRO773 protein

Information sourced from Uniprot.org

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